The GC-VUV method for the rapid identification and quantification of synthetic drugs of abuse is described.
This article in the Feb 2017 edition of The Column describes the results of a pilot study focused on trace water determination in common organic solvents using an ionic liquid stationary phase of GC column in a GC-VUV platform.
A method is described for the analysis and deconvolution of dimethylnaphthalene isomers using gas chromatography vacuum ultraviolet (GC-VUV) spectroscopy and theoretical computations. Dimethylnapthalenes were used as a model to establish limits of peak overlap deconvolution. It was found that, under reasonable injection conditions, all of the pairwise overlapping isomers tested could be deconvoluted up to nearly two orders of magnitude (up to 99:1) in relative abundance. These experimental deconvolution values were in agreement with theoretical covariance calculations performed for two of the dimethylnaphthalene isomers.
A pseudo-absolute method is described which had the ability to experimentally evaluate the sources of sample loss and gain associated with sample introduction into a typical gas chromatograph. In addition to conventional methods of quantification (internal and external standard), gas chromatography - vacuum ultraviolet (GC-VUV) spectroscopy has the potential for pseudo-absolute quantification of analytes based on pre-recorded cross sections (well-defined absorptivity across the 120–240 nm wavelength range recorded by the detector) without the need for traditional calibration. The pseudo-absolute quantification capability of the VUV detector provides a new means for carrying out system performance checks and potentially for solving challenging quantitative analytical problems.
A gas chromatographic method based on vacuum ultraviolet spectroscopic detection (GC-VUV) was developed and applied to analyze 41 terpenes in order to provide highly featured and easily differentiated spectra with good specificity for qualitative identification. This technique achieved deconvolution of co-eluting samples and demonstrated to be a powerful tool for reliable, accurate qualitative and quantitative analysis of terpenes from complex natural mixtures.
Kevin A. Schug, Ph.D.
Associte Professor and Shimadzu Distinguished
Professor of Analytical Chemistry
The University of Texas at Arlington
Mark R. Emmett, Ph. D.
University of Texas Medical Branch Galveston
UTMB Cancer Research Center